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Performance freak
Quick Answer : Do not use GUID as primary key
As Kimberly Tripp - the Queen of Indexing - and others have stated a great many times - a GUID as the clustering key isn't optimal, since due to its randomness, it will lead to massive page and index fragmentation and to generally bad performance.
https://www.sqlskills.com/blogs/kimberly/guids-as-primary-keys-andor-the-clustering-key/
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